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Research interests

The Heart and Energy

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Our long-term research objective is to elucidate the molecular and cellular mechanisms that control mitochondrial calcium, ATP, reactive oxygen species (ROS), and fission/fusion dynamics and translate this knowledge to our understanding of human health and disease.
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Research lines

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  • Mitochondria-SR Tethering: It's role in cardiac bioenergetics and Ca2+ dynamics

 

  • Ca2+ and ROS crosstalk signaling in cardiac mitochondria

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  • Trpm2: A novel target in Onco-cardiology

 

  • Dynamin-Related Protein 1 (Drp1) regulates Cardiac Excitation-Contraction-Bioenergetics coupling

 

  • Structural-Functional zoning of the mitochondrion in cardiac Ca2+, ROS, and energetics regulation

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1020 Locust St, PA, 19107 Philadelphia

Tel: 215-503-0445

  • 68747470733a2f2f6c68342e676f6f676c657573
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