Selected Publications

SPG7 targets the m-AAA protease complex to process MCU for uniporter assembly, Ca2+ influx, and regulation of mitochondrial permeability transition pore opening. Hurst S, Baggett A, Csordas G, Sheu SS. J Biol Chem. 2019 Jul 12;294(28):10807-10818. doi: 10.1074/jbc.RA118.006443. Epub 2019 May 16.

Mitochondrial Ca2+ concentrations in live cells: quantification methods and discrepancies. Fernandez-Sanz C, De la Fuente S, Sheu SS.

FEBS Lett. 2019 Jul;593(13):1528-1541. doi: 10.1002/1873-3468.13427. Epub 2019 May 18. Review.

SR-mitochondria communication in adult cardiomyocytes: A close relationship where the Ca2+ has a lot to say. De la Fuente S, Sheu SS.

Arch Biochem Biophys. 2019 Mar 15;663:259-268. doi: 10.1016/j.abb.2019.01.026. Epub 2019 Jan 24. Review.

Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation.

Miller BA, Wang J, Song J, Zhang XQ, Hirschler-Laszkiewicz I, Shanmughapriya S, Tomar D, Rajan S, Feldman AM, Madesh M, Sheu SS, Cheung JY. J Cell Physiol. 2019 Jan 13. doi: 10.1002/jcp.28146. [Epub ahead of print]

Spatial Separation of Mitochondrial Calcium Uptake and Extrusion for Energy-Efficient Mitochondrial Calcium Signaling in the Heart. De La Fuente S, Lambert JP, Nichtova Z, Fernandez Sanz C, Elrod JW, Sheu SS, Csordás G. Cell Rep. 2018 Sep 18;24(12):3099-3107.e4. doi: 10.1016/j.celrep.2018.08.040.

Why don't mice lacking the mitochondrial Ca2+ uniporter experience an energy crisis? Wang P, Fernandez-Sanz C, Wang W, Sheu SS. J Physiol. 2018 Sep 15. doi: 10.1113/JP276636. [Epub ahead of print]

Time course of liver mitochondrial function and intrinsic changes in oxidative phosphorylation in a rat model of sepsis. Eyenga P, Roussel D, Morel J, Rey B, Romestaing C, Gueguen-Chaignon V, Sheu SS, Viale JP. Intensive Care Med Exp. 2018 Sep 5;6(1):31. doi: 10.1186/s40635-018-0197-y.

Protein kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes. Jhun BS, O-Uchi J, Adaniya SM, Mancini TJ, Cao JL, King ME, Landi AK, Ma H, Shin M, Yang D, Xu X, Yoon Y, Choudhary G, Clements RT, Mende U, Sheu SS.J Physiol. 2018 Mar 1;596(5):827-855. doi: 10.1113/JP275418. Epub 2018 Jan 25.

Regulation of mitochondrial bioenergetics by the non-canonical roles of mitochondrial dynamics proteins in the heart. Wang W, Fernandez-Sanz C, Sheu SS. Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt B):1991-2001. doi: 10.1016/j.bbadis.2017.09.004. Epub 2017 Sep 14. Review.

The Mitochondrial Ca2+ Uniporter: Structure, Function, and Pharmacology. Mishra J, Jhun BS, Hurst S, O-Uchi J, Csordás G, Sheu SS. Handb Exp Pharmacol. 2017;240:129-156. doi: 10.1007/164_2017_1. Review.

A novel fission-independent role of dynamin-related protein 1 in cardiac mitochondrial respiration. Zhang H, Wang P, Bisetto S, Yoon Y, Chen Q, Sheu SS, Wang W. Cardiovasc Res. 2017 Feb;113(2):160-170. doi: 10.1093/cvr/cvw212. Epub 2016 Oct .

Strategic Positioning and Biased Activity of the Mitochondrial Calcium Uniporter in Cardiac Muscle. De La Fuente S, Fernandez-Sanz C, Vail C, Agra EJ, Holmstrom K, Sun J, Mishra J, Williams D, Finkel T, Murphy E, Joseph SK, Sheu SS, Csordás G. J Biol Chem. 2016 Oct 28;291(44):23343-23362. Epub 2016 Sep 16.

Mitochondrial Ca2+ and regulation of the permeability transition pore. Hurst S, Hoek J, Sheu SS. J Bioenerg Biomembr. 2017 Feb;49(1):27-47. doi: 10.1007/s10863-016-9672-x. Epub 2016 Aug 6. Review.

Mitochondrial Flash: Integrative Reactive Oxygen Species and pH Signals in Cell and Organelle Biology. Wang W, Gong G, Wang X, Wei-LaPierre L, Cheng H, Dirksen R, Sheu SS.Antioxid Redox Signal. 2016 Sep 20;25(9):534-49. doi: 10.1089/ars.2016.6739. Epub 2016 Jul 14. Review.

The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways. Jhun BS, Mishra J, Monaco S, Fu D, Jiang W, Sheu SS, O-Uchi J.Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C67-80. doi: 10.1152/ajpcell.00319.2015. Epub 2016 Apr 27. Review.

The SR/ER-mitochondria calcium crosstalk is regulated by GSK3β during reperfusion injury. Gomez L, Thiebaut PA, Paillard M, Ducreux S, Abrial M, Crola Da Silva C, Durand A, Alam MR, Van Coppenolle F, Sheu SS, Ovize M. Cell Death Differ. 2015 Nov;22(11):1890. doi: 10.1038/cdd.2015.118. No abstract available.

Isoform-specific dynamic translocation of PKC by α1-adrenoceptor stimulation in live cells. O-Uchi J, Sorenson J, Jhun BS, Mishra J, Hurst S, Williams K, Sheu SS, Lopes CM. Biochem Biophys Res Commun. 2015 Sep 25;465(3):464-70. doi: 10.1016/j.bbrc.2015.08.040. Epub 2015 Aug12.

Mitochondrial flash as a novel biomarker of mitochondrial respiration in the heart. Gong G, Liu X, Zhang H, Sheu SS, Wang W.Am J Physiol Heart Circ Physiol. 2015 Oct;309(7):H1166-77. doi: 10.1152/ajpheart.00462.2015. Epub 2015 Aug 14.

The SR/ER-mitochondria calcium crosstalk is regulated by GSK3β during reperfusion injury. Gomez L, Thiebaut PA, Paillard M, Ducreux S, Abrial M, Crola Da Silva C, Durand A, Alam MR, Van Coppenolle F, Sheu SS, Ovize M.Cell Death Differ. 2016 Feb;23(2):313-22. doi: 10.1038/cdd.2015.101. Epub 2015 Jul 24. Erratum in: Cell Death Differ. 2015 Nov;22(11):1890.

Complete List of Published Work in PubMed:

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