Selected Publications
Selected Publications
Selected Publications
Selected Publications
Selected Publications
Lab members
Shey-Shing Sheu
Group Leader
The overall goal of our research is to elucidate the fundamental principles in complex cardiac health and disease through an integrated paradigm of mitochondrial Ca2+, ROS, and ATP co-operative signaling mechanisms in spatial and temporal micro-domains. Our research vision is to improve health and cure disease through toning mitochondrial energetics, Ca2+, and redox signaling.
Yuexing Yuan
Research Associate
I received my Ph.D. in Molecular Genetics in 2006 from the Chinese Academy of Sciences, Shanghai.
My major task in our lab is to study the function of Ryanodine Receptors (RyR) in the heart.
My specialty is Echocardiography.
Sergio De la Fuente
PostDoc
I obtained my Ph.D. at the University of Valladolid, Spain. My topic was the development of new tools to measure Ca2+ concentrations in cellular organelles. My current research focus is on the mitochondrial Ca2+ fluxes in adult cardiac cells, especially in the mitochondrial Ca2+ uptake through the mitochondrial Calcium uniporter complex (MCU).
Celia Fernandez
PostDoc
My research is focused on the investigation of the non-canonical function of dynamin-related protein 1 (DRP1) in physiological excitation-contraction bioenergetics (ECB) coupling regulation in cardiac tissue.
Marilen
Federico
PostDoc
I got my Ph.D. at the National University of La Plata, focused on EC coupling and mitochondria function in the prediabetic hearts. The topic of my current postdoctoral research in Dr. Sheu’s lab is the structure, location and functional aspect of PTP in the heart related to the physiological excitation-contraction bioenergetics.
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Pierre Enyga
Physician
Hi, I am Pierre. Over the past few years I am visiting Dr. Sheu's Lab to work on mitochondria structure in the development of cardiac arrhythmia during severe sepsis. For the most part I am working as a clinical doctor at the University Hospital in Lyon.
Caitlyn Cardetti
PostDoc
I received my Ph.D. in Molecular and Cellular Pharmacology from Stony Brook University in New York. My PhD dissertation work focused on the role of the protein, Neugrin in mitochondrial RNA processing and mitoribosome assembly. My current postdoctoral research in Dr. Sheu’s lab is focused on establishing better understanding of the Ca2+ "zoning" within the mitochondria of the cardiomyocyte.
Hui-Ying Tsai
Research Assistant
After my master's degree and a year of work experience as a research assistant in Taiwan, I came to Dr. Sheu’s lab in 2019. I am studying the mechanism of mitochondria and Ca2+ regulation in cardiomyocytes. In addition, I am helping to organize the lab and maintain the animal colony.